NADPH dependent superoxide generation in the ovary and uterus of mice during estrous cycle and early pregnancy |
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Authors: | Jain S Saxena D Kumar G P Laloraya M |
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Affiliation: | School of Life Sciences, Devi Ahilya University, Vigyan Bhawan, Indore, India. |
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Abstract: | NADPH dependent O2- production in the ovary and uterus of cycling and pregnant mice was estimated employing a novel technique of time-lapse electron spin resonance enhancement of a superoxide-trapping spin trap. The NADPH dependent O2- generation in the mouse ovary increased during the early pre-ovulatory phase in cycling females and during extended luteal phase in pregnant animals. A peak of uterine NADPH dependent O2- production at proestrous in the cycling animals at pre-implantation phase in pregnant animals suggested a contribution of this enzyme towards generating high levels of superoxide anion radical during the respective stages. Both ovarian and uterine NADPH dependent O2- production appeared to be LH-inducible. |
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