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Induction by 5-bromodeoxyuridine of sex-linked lethal mutations in spermatogenous cells of Drosophila melanogaster |
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| Authors: | Berwind P. Kaufmann and Helen Gay |
| Affiliation: | Department of Zoology, and Cytogenetics Laboratory of Carnegie Institution of Washington, University of Michigan, Ann Arbor, Mich., U.S.A. |
| Abstract: | Injection of adult males of Drosophila melanogaster with a solution of 5-bromodeoxyuridine (BUdR) induced sex-linked lethal mutations but no chromosomal rerrangements. Application of the brood method suggests that the vast majority of the detected sex-linked lethals were induced in spermatozoa or spermatids. The findings suggest that secondary effects rather than an immediate direct involvement of DNA account for the mutagenic action of BUdR in D. melanogaster. |
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