Supported synthesis of ferrocene modified oligonucleotides as new electroactive DNA probes |
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| Authors: | Navarro Aude-Emmanuelle Spinelli Nicolas Chaix Carole Moustrou Corinne Mandrand Bernard Brisset Hugues |
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| Affiliation: | Groupe de Chimie Organique et Matériaux Moléculaires, UMR CNRS 6114, Faculté des Sciences de Luminy, case 901, 163 avenue de Luminy, 13288 Marseille Cedex 9, France. |
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| Abstract: | The use of 1-[3-O-(2-cyanoethyl-N,N-diisopropylphosphor amidityl)propyl]ferrocene and 1-[3-O-dimethoxytrityl propyl]-1'-[3'-O-(2-cyanoethyl-N,N-diisopropylphosphoramidityl) propyl] ferrocene as reactive synthons for DNA/RNA synthesizer allows to generate ferrocene-labelled oligonucleotides with remarkable DNA detection properties. |
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