| 基质金属蛋白酶与体外循环肺损伤研究进展 |
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| 引用本文： | Wang CT,Jing H. 基质金属蛋白酶与体外循环肺损伤研究进展[J]. 生理科学进展, 2004, 35(1): 35-38 |
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| 作者姓名： | Wang CT Jing H |
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| 作者单位： | 南京军区南京总医院心胸外科,南京,210002 |
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| 摘 要： | 肺泡 毛细血管基底膜损伤是体外循环 (CPB)术后肺损伤发生和发展的主要病理过程 ,基质金属蛋白酶 (MMPs)可能通过降解细胞外基质、调节细胞因子而参与CPB所致肺损伤的发生 ,研究MMPs在CPB肺损伤中的作用机制 ,对于防治CPB术后肺损伤的发生和发展具有重要意义
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| 关 键 词： | 基质金属蛋白酶 体外循环 肺损伤 |
Current progress of matrix metalloproteinase in acute lung injury following cardiopulmonary bypass |
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| Wang Chang-Tian,Jing Hua. Current progress of matrix metalloproteinase in acute lung injury following cardiopulmonary bypass[J]. Progress in Physiological Sciences, 2004, 35(1): 35-38 |
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| Authors: | Wang Chang-Tian Jing Hua |
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| Affiliation: | Department of Cardiothoracic Surgery, Nanjing General Hospital of Nanjing Command, Nanjing 210002. |
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| Abstract: | Degradation of basement membrane of pulmonary capillaries was the main pathological feature of lung injury following cardiopulmonary bypass (CPB). Matrix metalloproteinases (MMPs) contributed to the development of lung injury following CPB via degrading extracellular matrix and regulating cytokines. So, understanding the effects of MMPs in the lung injury following CPB may be helpful to prevent and treat the complications mentioned above. |
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| Keywords: | Matrix metalloproteinase Cardiopulmonary bypass Lung injury |
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