Triterpenoids. Part 21: Oleanolic acid azaderivatives as percutaneous transport promoters |
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| Authors: | Zaprutko Lucjusz Partyka Danuta Bednarczyk-Cwynar Barbara |
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| Institution: | Department of Organic Chemistry, Pharmaceutical Faculty, Poznan University of Medical Sciences, Poznań, Poland. |
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| Abstract: | Some new oleanolic acid derivatives with lactame and thiolactame structures in the A- or C-ring were prepared and tested as percutaneous transport promoters in vitro. Their activity was comparable with activity of N-dodecylcaprolactame (Azone). A-Thiolactame derivative of methyl oleanolate (13) was the most effective compound. |
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