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Segregation of Tay-Sachs and Sandhoff alleles in a non-Jewish family. |
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| Authors: | A B Lane E Young and T Jenkins |
| Abstract: | A non-Jewish family is presented in which the genes for Tay-Sachs disease and Sandhoff disease are segregating. Individuals heterozygous for both alleles have low serum and white cell total hexosaminidase levels together with a proportion of heat-labile hexosaminidase A (HEX A) which falls in the normal range. The individuals would not be detected as carriers of Tay-Sachs disease or Sandhoff disease in a population screening program. |
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