Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans |
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Authors: | Swierczynski Julian Zabrocka Lidia Goyke Elzbieta Raczynska Sylwia Adamonis Walenty Sledzinski Zbigniew |
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Affiliation: | (1) Department of Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland;(2) Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland;(3) Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland;(4) Department of General Surgery and Transplantology, Medical University of Gdansk, Gdansk, Poland |
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Abstract: | The primary purpose of this investigation was to determine whether adipose tissue glycerol 3-phosphate dehydrogenase activity is associated with human obesity. The data presented in this paper indicate that the glycerol 3-phosphate dehydrogenase activity in adipose tissue from morbidly obese subjects is approximately 2-fold higher than from lean individuals. Moreover, positive correlation between adipose tissue glycerol 3-phosphate dehydrogenase activity and body mass index (BMI) (r = 0.5; p < 0.01) was found. In contrast, the adipose tissue fatty acid synthase (FAS) and ATP-citrate lyase (ACL) activities in morbidly obese patients are significantly lower than in lean subjects. Furthermore, negative correlation between adipose tissue FAS activity and BMI (r = –0.3; p < 0.05) as well as between ACL activity and BMI (r = –0.3; p < 0.05) was found.These data indicate that elevated glycerol 3-phosphate dehydrogenase might contribute to the increase of triacylglycerol (TAG) synthesis in obese subjects, however, fatty acids necessary for glycerol 3-phosphate esterification must be derived (because of lower FAS and ACL activities) mainly from TAG in circulating lipoproteins formed in liver (VLDL), and/or from the intake with food (chylomicrons).The conclusion is, that the enhanced activity of glycerol 3-phosphate dehydrogenase, and hence the generation of more glycerol 3-phosphate in adipose tissue offers a novel explanation for increased TAG production in adipose tissue of obese subjects. |
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Keywords: | ATP-citrate lyase fatty acid synthase glycerol 3-phosphate dehydrogenase human obesity |
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