Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis |
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Authors: | Mieke Delvaeye Astrid De Vriese Femke Zwerts Inge Betz Michael Moons Monica Autiero Edward M Conway |
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Institution: | (1) KU Leuven, VIB Vesalius Research Center (VRC), Gasthuisberg O&N-1, Herestraat 49, 3000 Leuven, Belgium |
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Abstract: | Background Normal growth and development of organisms requires maintenance of a dynamic balance between systems that promote cell survival
and those that induce apoptosis. The molecular mechanisms that regulate these processes remain poorly understood, and thus
further in vivo study is required. Survivin is a member of the inhibitor of apoptosis protein (IAP) family, that uniquely also promotes mitosis
and cell proliferation. Postnatally, survivin is hardly detected in most tissues, but is upregulated in all cancers, and as
such, is a potential therapeutic target. Prenatally, survivin is also highly expressed in several tissues. Fully delineating
the properties of survivin in vivo in mice has been confounded by early lethal phenotypes following survivin gene inactivation. |
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