In Vitro Evaluation of Proniosomes as a Drug Carrier for Flurbiprofen |
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Authors: | Mahmoud Mokhtar Ahmed Ibrahim Omaima A Sammour Mohamed A Hammad Nagia A Megrab |
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Institution: | (1) Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt;(2) Department of Drug Technology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt |
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Abstract: | The purpose of the present investigation is to formulate and evaluate proniosomal transdermal carrier systems for flurbiprofen.
Proniosomes were prepared using various non-ionic surfactants, namely span 20 (Sp 20), span 40 (Sp 40), span 60 (Sp 60) and
span 80 (Sp 80) without and with cholesterol at percentages ranging from 0% to 50%. The effect of surfactant type and cholesterol
content on drug release was investigated. Drug release was tested by diffusion through cellophane membrane and rabbit skin.
Drug release from the prepared systems was compared to that from flurbiprofen suspensions in distilled water and HPMC (hydroxypropylmethylcellulose)
gels. In case of Sp 20 and Sp 80, the added amount of cholesterol affected the preparation type to be either proniosomal alcoholic
solutions or liquid crystalline gel systems. On the other hand, both Sp 40 and Sp 60 produced gel systems in presence or absence
of cholesterol. Microscopic observations showed that either proniosomal solutions or gel formulations immediately converted
to niosomal dispersions upon hydration. Due to the skin permeation barrier, rabbit skin showed lower drug diffusion rates
compared to cellophane membrane. The proniosomal composition controlled drug diffusion rates to be either faster or slower
than the prepared flurbiprofen suspensions in HPMC gels or distilled water, respectively. In conclusion, this study demonstrated
the possibility of using proniosomal formulations for transdermal drug delivery. |
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Keywords: | cholesterol flurbiprofen gel liquid crystal non-ionic surfactant proniosomes |
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