Mechanism of disorders in neurotrophic regulation of the level of striated skeletal muscle polarization by botulinum toxin

Muscle reinnervation was studied in experiments on rats given intramuscular injection of sublethal doses of botulinum toxin. It has been established that botulinum toxin not influencing the formation of functioning myoneural synapses leads to long-term persistence of depolarization of reinnervated muscle cells without changes in passive biophysical properties of their sarcoplasmatic membranes.