Drosophila melanogaster flatline encodes a myotropin orthologue to Manduca sexta allatostatin |
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Authors: | Price Mitchell D Merte Janna Nichols Ruthann Koladich Peter M Tobe Stephen S Bendena William G |
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Institution: | Department of Biology, Queen's University, K7L 3N6, Kingston, Ontario, Canada. |
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Abstract: | We identified a Drosophila melanogaster gene encoding a peptide that dramatically decreases spontaneous muscle contractions and, correspondingly, named the peptide flatline (FLT). This gene consisted of 4 exons and was cytologically localized to 32D2-3. Processing of a predicted 122 amino acid precursor would release pEVRYRQCYFNPISCF that differs from Manduca sexta allatostatin (Mas-AST) by one amino acid, Y4-->F4. FLT does not act as an allatostatin. In situ tissue hybridization further suggests FLT is a novel brain-gut peptide and specifically, the measured activity indicates that it is a potent myotropin. Despite its profound myotropic effect, pupae injected with FLT eclosed. |
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