Detection of P-glycoprotein on endothelial and endocrine cells of the human pancreatic islets by C 494 monoclonal antibody |
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Authors: | D. Bani M. L. Brandi C. A. Axiotis T. Bani-Sacchi |
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Affiliation: | (1) Department of Human Anatomy and Histology, Section of Histology, University of Florence, Florence, Italy;(2) Department of Clinical Physiopathology, Endocrinology Unit, University of Florence, Florence, Italy;(3) Albany Medical College, Albany, New York, USA;(4) Dipartimento di Anatomia Umana e Istologia, Sezione di Istologia Enrico Allara, Viale G. Pieraccini 6, I-50139 Firenze, Italy |
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Abstract: | Summary P-glycoprotein, an integral membrane protein acting as an energy-dependent efflux pump, has been detected immunocytochemically in the human pancreatic islets using C 494 monoclonal antibody. Intense P-glycoprotein immunoreactivity was found in both endothelial cells of islet blood capillaries and in endocrine cells. Strong expression of P-glycoprotein has been found in the capillary blood vessels at blood-tissue barrier sites and in numerous kinds of cells with secretory/excretory function. Therefore the present findings suggest that P-glycoprotein may play a role in controlling the composition of the extracellular fluids and the intracellular milieu of endocrine islet cells and possibly in regulating their secretory activity. |
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