Localization of the humanRGR opsin gene to chromosome 10q23 |
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| Authors: | X -N Chen J R Korenberg M Jiang D Shen H K W Fong |
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| Affiliation: | (1) Medical Genetics Birth Defects Center, Ahmanson Department of Pediatrics, Cedars-Sinai Research Institute/UCLA, 90048 Los Angeles, CA, USA;(2) Department of Anesthesiology, UCLA, 90024 Los Angeles, CA, USA;(3) Doheny Eye Institute, 90033 Los Angeles, CA, USA;(4) Departments of Microbiology and Ophthalmology, University of Southern California School of Medicine, 90033 Los Angeles, CA, USA |
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| Abstract: | The humanRGR gene encodes an opsin protein (retinal G protein-coupled receptor), which is expressed in Müller cells and the retinal pigment
epithelium and is thought to play a role in the visual process. To investigate a possible linkage of theRGR gene to retinal dystrophies, the locus of the gene was mapped on human metaphase chromosomes. Genomic and cDNA fragments
of the humanRGR gene were used as probes for fluorescence in situ hybridization. Analysis of the fluorescence signals on high-resolution
banded chromosomes showed that theRGR gene is localized to human chromosome lOq23. This result now provides for the rapid analysis of this gene with respect to
inherited diseases of the retina. |
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