The transport machinery for the import of preproteins across the outer mitochondrial membrane |
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| Authors: | Ryan M T Wagner R Pfanner N |
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| Institution: | 1. Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Straße 7, D-79104, Freiburg, Germany;2. Biophysik, Universität Osnabrück, FB Biologie/Chemie, D-49034, Osnabrück, Germany;1. Heart Center, Shanghai Jiao Tong University Affiliated Sixth People''s Hospital, Shanghai, 200233, PR China;2. Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, PR China;3. Department of Anesthesia, University of Iowa Hospitals & Clinics, Iowa City, IA, 52242, USA;1. Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, PR China;2. Xiangya Hospital, Central South University, Changsha, PR China;3. School of Basic Medical Science, Changsha Medical University, Changsha, PR China;4. Key Laboratory for Fertility Regulation and Birth Health of Minority Nationalities of Yunnan Province, Judicial Expertise Center, Yunnan Population and Family Planning Research Institute, Kunming, PR China;1. College of Horticulture, Qingdao Agricultural University, Qingdao 266109, China;2. College of Life Sciences, Key Laboratory of Plant Biotechnology of Shandong Province, Qingdao Agricultural University, Qingdao 266109, China;1. Department of Biomedicine, University Basel, Basel, Switzerland;2. Department of Ophthalmology, University Basel, Basel, Switzerland |
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| Abstract: | In order for proteins to be imported into subcellular compartments, they must first traverse the organellar membranes. In mitochondria, hydrophilic protein channels in both the outer and inner membranes serve such a purpose. Recently, the channel protein of the outer mitochondrial membrane was identified to be Tom40. Tom40 is found in a high molecular weight complex termed the general import pore (GIP) complex where it is tightly associated with the receptor protein Tom22 along with Tom7, Tom6 and Tom5. Tom7 and Tom6 seem to modulate the dynamics of the GIP complex while Tom5 is involved in preprotein transfer from receptors to Tom40. The receptor proteins Tom70 and Tom20 associate with this complex in a weaker manner where they are involved in the initial recognition of preproteins. This review focuses on the identification and characterisation of the transport machinery of the outer mitochondrial membrane and how they are involved in the co-ordination and regulation of events required for the translocation of preproteins into mitochondria. |
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