Asbestos catalyzes the formation of the 6-oxobenzo[a]pyrene radical from 6-hydroxybenzo[a]pyrene |
| |
| Authors: | P Graceffa S A Weitzman |
| |
| Affiliation: | Boston Biomedical Research Institute, Department of Muscle Research, Massachusetts 02114. |
| |
| Abstract: | Crocidolite asbestos catalyzes the oxidation of 6-hydroxybenzo[a]pyrene, a metabolite of benzo[a]pyrene, to the 6-oxobenzo[a]pyrene radical as determined by electron spin resonance spectroscopy. This may be a mechanism whereby inhaled asbestos enhances the incidence of lung cancer induced by cigarette smoke, which contains benzo[a]pyrene. |
| |
| Keywords: | |
|
|
