Genetic analysis of testis weight and fertility in an interspecies hybrid congenic strain for Chromosome X |
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| Authors: | Rosemary W Elliott Darla R Miller R Scott Pearsall Colleen Hohman Yuke Zhang Diane Poslinski Debra A Tabaczynski Verne M Chapman |
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| Institution: | (1) Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, New York State Department of Health, 666 Elm Street, Buffalo, New York 14263, USA, US |
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| Abstract: | A hybrid congenic strain, C57BL/6J.SPRET-Hprt
a
, carrying 17 map units of Chromosome (Chr) X from Mus spretus on a background of C57BL/6J, has the novel phenotype of low fertility associated with small testis weight. In histological
cross-section, many of the tubules in the testes of these congenic mice are empty except for Sertoli cells, while the other
tubules appear to be normal. The gene, interspecific hybrid testis weight 1 (Ihtw1) causing this phenotype, has been fine mapped by using the strategy of generating subcongenic strains from recombinants within
the congenic region. Genetic and phenotypic analysis of the subcongenic strains has defined a critical region of 1.8 map units
for Ihtw1. This region of the genetic map is orthologous to the region on human Chr X containing the gene for the Borjeson-Forssman-Lehman
syndrome, an inherited disease in which males show microorchidism.
Received: 12 June 2000 / Accepted: 8 September 2000 |
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