QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography |
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| Authors: | Wang Sumin Yang Gengliang Zhang Hua Liu Haiyan Li Zhiwei |
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| Institution: | College of Pharmacy, Hebei University, Baoding 071002, China; Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China. |
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| Abstract: | The capability of biopartitioning micellar chromatography (BMC) to describe and estimate pharmacological parameters of cardiovascular system drugs has been studied. The retention of cardiovascular system drugs was studied using different pH of Brij-35 as micellar mobile phase in modified C(18) stationary phase. Quantitative retention-activity relationships (QRAR) in BMC were investigated for these compounds. An adequate correlation between the retention factors (log k) and the toxicity (LD(50)) of cardiovascular system drugs was obtained. |
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