生物大分子质谱电离技术的突破及核磁共振三维结构测定方法的建立——2002年诺贝尔化学奖简介

2002年诺贝尔化学奖授予了质谱和核磁共振领域的三位科学家以表彰他们对生物大分子鉴定及结构分析方法做出的贡献．其中两位科学家J．B．Fenn和K．Tanaka分别发展了生物大分子质谱分析的软解吸电离方法；另一科学家K．Wüthrich则将核磁共振技术成功地应用于生物大分子如蛋白质的溶液三维结构测定．他们的研究成果已使质谱和核磁共振技术成为生物大分子强有力的研究手段，极大地促进了生物大分子的研究进程，必将对整个生命科学研究产生深远的影响．

Mass Spectrometry (MS) and Nuclear Magnetic Resonance(NMR) Revolutionized The Study of Biological Macromolecules

The progress of science is in part attributed to the development of new methodologies. The application of mass spectrometry (MS) and nuclear magnetic resonance (NMR) in the study of biological macromolecules is such a representative example, which is the subject of this year's Nobel prize award in chemistry shared by three scientists. The works include the development of soft desorption ionization methods for mass spectrometric analysis of biological macromolecules and the development of NMR for determining the three-dimensional structure of biological macromolecules in solution. These developments revolutionized the analytical methods for biomolecules such as proteins and facilitate the study of biological macromolecules so much enough to have deep effects on the whole life sciences.