Relief of palmityl CoA inhibition of citrate synthase by long-chain acylcarnitine derivatives |
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| Authors: | I B Fritz |
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| Affiliation: | 1. Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;2. Department of Gastroenterology, The People''s Hospital of Jianyang City, Sichuan 641400, China |
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| Abstract: | Inhibition of citrate synthase by incubation with palmityl CoA could be in large part prevented by concomitant incubation of enzyme with (+)-palmitylcarnitine, (−)-palmitylcarnitine or DL-stearylcarnitine. DL-Octanylcarnitine was less effective while butyrylcarnitine was without any protective action. The molar ratio of palmitylcarnitine to palmityl CoA required for relief of palmityl CoA inhibition was lowered at elevated concentrations of albumin. |
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