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New derivatives of alkyl-and aminocarbonylphosphonic acids containing 3′-azido-3′-deoxythymidine |
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| Authors: | M. V. Jasko A. V. Shipitsyn A. L. Khandazhinskaya E. A. Shirokova P. N. Sol’yev O. A. Plyasunova A. G. Pokrovskii |
| Affiliation: | (1) Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia;(2) Vector State Research Center of Virology and Biotechnology, Kol’tsovo, Novosibirsk oblast, 633159, Russia |
| Abstract: | New 5′-phosphonates of 3′-azido-3′-deoxythymidine were synthesized and shown to be low-toxic and markedly active in MT-4 cell cultures infected with HIV-1. |
| Keywords: | 3′ -azido-3′ -deoxythymidine 3′ -azido-3′ -deoxythymidine 5′ -H-phosphonate (Nikavir?) human immunodeficiency virus nucleoside phosphonates |
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