Antitumor activity of titanocene amino acid complexes |
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Authors: | Petra Köpf-Maier I C Tornieporth-Oetting |
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Affiliation: | (1) Institut für Anatomie, Freie Universität Berlin, Berlin, Germany;(2) Institut für Anorganische und Analytische Chemie, Technische Universität Berlin, Berlin, Germany;(3) Institut für Anatomie, Freie Universität Berlin, Königin-Luise-Strasse 15, D-14195 Berlin, Germany |
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Abstract: | Seven ionic titanocene -amino acid (aa) complexes (C5H5)2Ti(aa)2]2+X]2
– with aa = glycine,l-alanine, 2-methylalanine,d-l-phenylalanine,d,l-4-fluorophenylalanine and X = Cl or AsF6, were investigated for antitumor activity against fluid Ehrlich ascites tumor growing in CF1 mice. These complexes are the first stable model compounds of titanocene units with protein components, synthesized from a water-like, methanolic medium. All titanocene amino acid complexes induced antitumor activity which was manifested by maximum cure rates ranging from 30 to 70% and increases in life span from 78 to 276% in comparison with untreated control animals. The complexes containing chloride as anion X were more effective than the hexafluoroarsenate derivatives, which surprisingly showed a low substance toxicity. In all cases, the antitumor activity of the ionic titanocene amino acid complexes tested was less pronounced than that of the neutral parent compound (C5H5)2TiCl2]. |
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Keywords: | antitumor activity Ehrlich ascites tumor mechanism of action titanocene amino acid complexes |
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