植物内生真菌抗肿瘤药物研究进展

癌症已经严重威胁人类的健康。从自然界中筛选更新的、更有效的抗癌药物已成为了该领域的研究重点。作为新型抗癌药物的潜在来源，众多从植物内生真菌分离的代谢产物被证明具有抗肿瘤的生物活性。这些内生真菌通常具有特殊的代谢途径，可以在其培养物中积累抗癌活性物质，如紫杉烷类、生物碱类、细胞松弛素、鬼臼毒素、布雷菲德菌素A等。将系统的介绍已分离自植物内生真菌的抗癌药物的研究进展，同时对内生真菌的抗癌药物筛选的策略和发展前景进行简要的展望。

Anticancer Agents from Endophytic Fungi

Various cancers have seriously threatened human' s health. Screening newer and more effective anticancer agents from natural sources to cure these diseases is the focus in research. As novel sources of potential medicine, a number of metabolites isolated from endophytic fungi have been proved to have anticancer bioactivity. Usually, these endophytic fungi have special biochemical pathway and they can accumulate anticancer agents in cultures such as taxane, alkaloids, cytochalasins, podophyllotoxin, brefeldin A and so forth. The research advance on anticancer agents purified from endophytic fungi is expatiated systemically. In addition, the strategy of screening anticancer agents as well as the prospect on this area is introduced briefly.