|
|||||
|
|
1H, 13C, and 15N resonance assignment of the TIR domain of human MyD88 |
|
| Authors: | Hidenori Ohnishi Hidehito Tochio Zenichiro Kato Takeshi Kimura Hidekazu Hiroaki Naomi Kondo Masahiro Shirakawa |
| Institution: | 1. Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu, 501-1194, Japan 2. Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto, 615-8510, Japan 3. Division of Structural Biology, Graduate School of Medicine, Kobe University, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan |
| Abstract: | Myeloid differentiating factor 88 (MyD88) is one of a critical adaptor molecule in the Toll-like receptor (TLR) signaling pathway. The TIR domain of MyD88 serves as a protein–protein interaction module and interacts with other TIR-containing proteins such as Mal (MyD88 adaptor-like) and Toll-like receptor 4 to form signal initiation complexes. Here we report the 15N, 13C, and 1H chemical shift assignments of the TIR domain of MyD88. The resonance assignments obtained in this work will contribute to the study of heteromeric TIR–TIR interactions between MyD88 and TIR-containing receptors or adaptors. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |