Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. |
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| Authors: | J B Bateman I Klisak T Kojis T Mohandas R S Sparkes T S Li M L Applebury C Bowes D B Farber |
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| Institution: | Vision Genetics Center, Jules Stein Eye Institute, Los Angeles, California. |
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| Abstract: | The gene encoding the beta-subunit of rod photoreceptor cGMP phosphodiesterase (gene symbol PDEB, homolog of the mouse rd gene) is mapped to human chromosome 4 using somatic cell hybrids and further localized to the chromosome band 4p16 using in situ hybridization. A mutation in the mouse gene underlies the recessive trait of retinal degeneration in the rd mouse. Thus, the human homolog is a candidate for lesions causing retinal degeneration. |
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