| Kisspeptins在孕早期血浆和胎盘组织中的表达及其意义 |
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| 引用本文： | 杨蓓,王永斌,徐宏,张保平,彭婧,赵文亭,张鹏,况海斌. Kisspeptins在孕早期血浆和胎盘组织中的表达及其意义[J]. 激光生物学报, 2011, 20(6): 791-794. DOI: 10.3969/j.issn.1007-7146.2011.06.015 |
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| 作者姓名： | 杨蓓 王永斌 徐宏 张保平 彭婧 赵文亭 张鹏 况海斌 |
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| 作者单位： | 1. 南昌大学基础医学院生理学教研室,江西南昌,330006
2. 南昌市第六人民医院,江西南昌,330003 |
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| 摘 要： | 目的:研究kisspeptins在孕早期血浆和胎盘组织中的表达,拟探讨其来源及其在妊娠中意义.方法:采用酶联免疫吸附法(ELISA),检测40例孕早期妇女和35例正常未妊娠妇女血浆kisspeptins的表达水平,且分析其与hCG的相关性;采用免疫组织化学方法进行其组织学定位.结果:(1)kisspeptins在妊娠组...
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| 关 键 词： | kisspeptins 妊娠 hCG 胎盘 表达 |
The Expression and Significance of Kisspeptins in Plasma and Placenta of Early Pregnancy |
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| YANG Bei,WANG Yongbin,XU Hong,ZHANG Baoping,PENG Jing,ZHAO Wenting,ZHANG Peng,KUANG Haibin. The Expression and Significance of Kisspeptins in Plasma and Placenta of Early Pregnancy[J]. ACTA Laser Biology Sinica, 2011, 20(6): 791-794. DOI: 10.3969/j.issn.1007-7146.2011.06.015 |
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| Authors: | YANG Bei WANG Yongbin XU Hong ZHANG Baoping PENG Jing ZHAO Wenting ZHANG Peng KUANG Haibin |
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| Affiliation: | 1＊) (1.Department of Physiology of Medical College,Nanchang Uniyersity,Nanchang 330006,Jiangxi,China; 2.The Sixth Hospital of Nanchang,Nanchang 330003,Jiangxi,China) |
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| Abstract: | Objective：To study the expression levels of kisspeptins in the plasma and placenta tissue,and investigate its origin and significance in early pregnancy.Methods：Using enzyme-linked immunosorbent assay（ELISA）,plasma kisspeptins were detected and analyzed its correlation with human chorionic gonadotropin（hCG） in 40 eases of pregnant women and 35 nornial non-pregnant women.Immunohistochemistry revealed histological localization of kisspeptin.Results： （1）Pregnant women had significantly higher plasma kisspeptin levels（982.46±239.41 pmol/L） than nonpregnant women（3.57±0.37pmol/L）（P0.001）.（2）Plasma levels of kisspeptins in pregnant women has a signifi- cant positive correlation with hCG（r=0.84,P=0.015）.（3） Immunohistocheniistry demonstrated that kisspeptins were strongly expressed in decidual cells and the syncytiotrophoblast,and weakly expressed in cytotrophoblast cells of chorionic villi,but not in extravillous trophoblasts.Conclusion：The expression levels of kisspeptins were significantly increased in early pregnancy,which may come from the decidual and placental tissue,and expression level of kisspeptins in the plasma could be used as a complementary marker for pregnancy. |
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| Keywords: | kisspeptins pregnancy hCG placenta expression |
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