Effect of mouse genotype on interferon production |
| |
Authors: | Edward De Maeyer Marie -Christine Hoyez Jaqueline De Maeyer-Guignard Donald W Bailey |
| |
Institution: | (1) Institut Curie, Université de Paris-Sud, Campus d'Orsay, 91405 Orsay, France;(2) The Jackson Laboratory, Bar Harbor, Maine |
| |
Abstract: | Upon induction with Newcastle disease virus, peritoneal macrophages derived from C57BL/6 mice produced ten times as much interferon as macrophages derived from BALB/c mice. This suggested that the alleles of theIf-1 locus are expressed in vitro by these cells. Further evidence for this was obtained by studying interferon production by peritoneal macrophages derived from seven recombinant inbred and one congenic line: in each case there was complete correlation between in vivo and in vitro phenotype: macrophages fromIf-1l mice were low producers in vitro, and macrophages fromIf-1
h
mice were high producers in vitro. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|