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Ultra-structural cell distribution of the melanoma marker iodobenzamide: improved potentiality of SIMS imaging in life sciences
Authors:Jean-Luc?Guerquin-Kern  Fran?ois?Hillion  Jean-Claude?Madelmont  Pierre?Labarre  Janine?Papon  Email author" target="_blank">Alain?CroisyEmail author
Institution:1.INSERM U-350, laboratoire Raymond Latarjet,Centre Universitaire,Orsay,France;2.CAMECA France,France;3.INSERM U-484,Centre de recherche INSERM,Clermont Ferrand cedex,France
Abstract:

Background  

Analytical imaging by secondary ion mass spectrometry (SIMS) provides images representative of the distribution of a specific ion within a sample surface. For the last fifteen years, concerted collaborative research to design a new ion microprobe with high technical standards in both mass and lateral resolution as well as in sensitivity has led to the CAMECA NanoSims 50, recently introduced onto the market. This instrument has decisive capabilities, which allow biological applications of SIMS microscopy at a level previously inaccessible. Its potential is illustrated here by the demonstration of the specific affinity of a melanoma marker for melanin. This finding is of great importance for the diagnosis and/or treatment of malignant melanoma, a tumour whose worldwide incidence is continuously growing.
Keywords:
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