Ultra-structural cell distribution of the melanoma marker iodobenzamide: improved potentiality of SIMS imaging in life sciences |
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Authors: | Jean-Luc?Guerquin-Kern Fran?ois?Hillion Jean-Claude?Madelmont Pierre?Labarre Janine?Papon Email author" target="_blank">Alain?CroisyEmail author |
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Institution: | 1.INSERM U-350, laboratoire Raymond Latarjet,Centre Universitaire,Orsay,France;2.CAMECA France,France;3.INSERM U-484,Centre de recherche INSERM,Clermont Ferrand cedex,France |
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Abstract: | Background Analytical imaging by secondary ion mass spectrometry (SIMS) provides images representative of the distribution of a specific
ion within a sample surface. For the last fifteen years, concerted collaborative research to design a new ion microprobe with
high technical standards in both mass and lateral resolution as well as in sensitivity has led to the CAMECA NanoSims 50, recently introduced onto the market. This instrument has decisive capabilities, which allow biological applications of SIMS
microscopy at a level previously inaccessible. Its potential is illustrated here by the demonstration of the specific affinity
of a melanoma marker for melanin. This finding is of great importance for the diagnosis and/or treatment of malignant melanoma,
a tumour whose worldwide incidence is continuously growing. |
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