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Microdetermination of caffeine in blood by gas chromatography—mass spectrometry |
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| Authors: | RL Merriman A Swanson MW Anders NE Sladek |
| Institution: | Department of Pharmacology, University of Minnesota, Minneapolis, Minn. 55455 U.S.A. |
| Abstract: | A micromethod for the quantitative analysis of caffeine present in small quantities (100 μl) of whole blood is described. It is based on the gas chromatographic—mass spectrometric analysis of chloroform extracts of biological samples. The method is relatively simple, rapid, specific and sensitive, as little as 20 ng of caffeine can be measured. |
| Keywords: | To whom correspondence should be directed Research Career Development Awardee of the National Cancer Institute USPHS 1-KO4-CA70383-05 |
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