Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1 |
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| Authors: | Tian Yong Breedveld Guido J Huang Shangzhi Oostra Ben A Heutink Peter Lo Wilson H Y |
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| Affiliation: | Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. |
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| Abstract: | ZNF333 is a novel human KRAB-zinc finger protein gene on chromosome 19p13.1 encompassing 14 exons. ZNF333 is highly expressed in heart and encodes a 665 amino acid protein that contains a rare combination of double KRAB-domains, each consisting of a classical KRAB-A and a highly divergent KRAB-B box at the N-terminus. ZNF333 further contains 10 C2H2 zinc finger motifs at the C-terminus. |
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