Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors |
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Authors: | Abdellatif Khaled R A Velázquez Carlos A Huang Zhangjian Chowdhury Morshed A Knaus Edward E |
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Institution: | Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8 |
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Abstract: | A group of (Z)-1,2-diphenyl-1-4-2-(4-methylpiperazin-1-yl)ethoxy]phenyl]but-1-enes were synthesized using methodologies that will allow incorporation of a 124I]iodine substituent at the para-position of either the C-1 phenyl ring or the C-2 phenyl ring, or a 18F]OCH2CH2F substituent at the para-position of the C-2 phenyl ring. These 124I] and 18F] radiotracers are designed as potential radiopharmaceuticals to image estrogen positive breast tumors using positron emission tomography (PET). |
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Keywords: | Tricyclic (Z)-olefins Estrogen positive breast tumors Positron emission tomography imaging |
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