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Coordination conjugates of therapeutic proteins with drug carriers: a new approach for versatile advanced drug delivery
Authors:Kejík Zdeněk  Bříza Tomáš  Králová Jarmila  Poučková Pavla  Král Aleš  Martásek Pavel  Král Vladimír
Affiliation:Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Abstract:We present here a general system for the coordination attachment of therapeutic proteins to a drug delivery system and its application in combined therapy. Proof of concept is demonstrated by the synthesis and testing of the targeted drug delivery system for cytostatics, which is based on a combination of the drug carrier Zn-porphyrin-cyclodextrin conjugates and their supramolecular coordination complexes with immunoglobulins. This system can be as readily used for a variety of therapeutic and targeting proteins including PAs, MAs, lectins, and HSA. Moreover, it allows combined photodynamic therapy, cell targeted chemotherapy and immunotherapy. When tested in a mouse model with human C32 carcinoma, the therapeutic superiority of the coordination assembly nanosystem was shown in comparison with the efficacy of building blocks used for the construction of the system.
Keywords:Combined cancer therapy   Photodynamic therapy   Cytostatics   Targeted drug delivery   Therapeutic proteins
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