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Predicted and experimental structures of integrins and beta-propellers
Authors:Springer Timothy A
Affiliation:Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. springeroffice@cbr.med.harvard.edu
Abstract:Integrins and other cell surface receptors have been fertile grounds for structure prediction experiments. Recently determined structures show remarkable successes, especially with beta-propeller domain predictions, and also reveal how ligand binding by integrins is conformationally regulated.
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