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Localization of the 31-amino-acid endothelin-1 in hamster tissue
Authors:Kakui Sae  Mawatari Kazuaki  Ohnishi Takamasa  Niwa Yasuharu  Tanoue Naomi  Harada Nagakatsu  Takahashi Akira  Izumi Keisuke  Nakaya Yutaka
Affiliation:Department of Nutrition, School of Medicine, Tokushima University, Tokushima, 3-18-15 Kuramoto-cho, 770-8503, Tokushima, Japan
Abstract:Endothelin (ET)-1(1-31) is a novel vasoconstrictor peptide produced by human mast cell chymase, which selectively cleaves big ET-1 at the Try(31)-Gly(32) bond. We investigated the localization of ET-1(1-31) in various hamster tissues by immunohistochemistry and compared it to the distribution of ET-1(1-21). We found that the localization and amount of ET-1(1-31) were different from those of ET-1(1-21) in each tissue. ET-1(1-31)-like immunoreactivities (IR) in the heart, lung, and adrenal gland were observed in the same areas as ET-1(1-21) but were significantly weaker, suggesting that ET-1(1-31) might play a role only in mast cell/chymase-related pathological conditions in these tissues. In the liver, ET-1(1-31)-like IR was strongly detected in Kupffer cells where ET-1(1-21)-like IR was seen more weakly. In the kidney, ET-1(1-31)-like IR was slightly higher than ET-1(1-21). These results suggest that ET-1(1-31) might have physiological roles distinct from those of ET-1(1-21) in some hamster tissues.
Keywords:Endothelin-1(1-31)   Liver   Kupffer cell   Kidney
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