Overexpression of WDR79 in non‐small cell lung cancer is linked to tumour progression |
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| Authors: | Yang Sun Chao Yang Jieying Chen Xin Song Zhen Li Minlan Duan Jianglin Li Xiaoxiao Hu Kuangpei Wu Guobei Yan Cai Yang Jing Liu Weihong Tan Mao Ye |
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| Institution: | 1. Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Molecular Engineering for Theranostics, Hunan University, Changsha, Hunan, China;2. College of Life and Environmental Sciences, Gannan Normal University, Ganzhou, Jiangxi, China;3. Cancer Biotherapy Center, Tumor Hospital of Yunnan Province Affiliated with Kunming Medical University, Kunming, Yunnan, China;4. State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, Hunan, China |
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| Abstract: | WD‐repeat protein 79 (WDR79), a member of the WD‐repeat protein family, acts as a scaffold protein, participating in telomerase assembly, Cajal body formation and DNA double‐strand break repair. Here, we first report that WDR79 is frequently overexpressed in cell lines and tissues derived from non‐small cell lung cancer (NSCLC). Knockdown of WDR79 significantly inhibited the proliferation of NSCLC cells in vitro and in vivo by inducing cell cycle arrest and apoptosis. WD‐repeat protein 79 ‐induced cell cycle arrest at the G0/G1 phase was associated with the expression of G0/G1‐related cyclins and cyclin‐dependent kinase complexes. We also provide evidence that WDR79 knockdown induces apoptosis via a mitochondrial pathway. Collectively, these results suggest that WDR79 is involved in the tumorigenesis of NSCLC and is a potential novel diagnostic marker and therapeutic target for NSCLC. |
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| Keywords: | lung cancer cell cycle apoptosis proliferation |
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