Silencing of Prrx1b suppresses cellular proliferation,migration, invasion and epithelial–mesenchymal transition in triple‐negative breast cancer |
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| Authors: | Zhi‐Dong Lv Zhao‐Chuan Yang Xiang‐Ping Liu Li‐Ying Jin Qian Dong Hui‐Li Qu Fu‐Nian Li Bin Kong Jiao Sun Jiao‐Jiao Zhao Hai‐Bo Wang |
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| Institution: | 1. Center of Diagnosis and Treatment of Breast Disease, The Affiliated Hospital of Qingdao University, Qingdao, China;2. Departments of Child Health Care, The Affiliated Hospital of Qingdao University, Qingdao, China;3. Central Laboratory of Molecular Biology, The Affiliated Hospital of Qingdao University, Qingdao, China;4. Cerebrovascular Disease Research Institute, The Affiliated Hospital of Qingdao University, Qingdao, China;5. Departments of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China |
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| Abstract: | Triple‐negative breast cancer (TNBC) is a highly aggressive tumour subtype associated with poor prognosis. The mechanisms involved in TNBC progression remains largely unknown. To date, there are no effective therapeutic targets for this tumour subtype. Paired‐related homeobox 1b (Prrx1b), one of major isoforms of Prrx1, has been identified as a new epithelial–mesenchymal transition (EMT) inducer. However, the function of Prrx1b in TNBC has not been elucidated. In this study, we found that Prrx1b was significantly up‐regulated in TNBC and associated with tumour size and vascular invasion of breast cancer. Silencing of Prrx1b suppressed the proliferation, migration and invasion of basal‐like cancer cells. Moreover, silencing of Prrx1b prevented Wnt/β‐catenin signaling pathway and induced the mesenchymal‐epithelial transition (MET). Taken together, our data indicated that Prrx1b may be an important regulator of EMT in TNBC cells and a new therapeutic target for interventions against TNBC invasion and metastasis. |
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| Keywords: | triple‐negative breast cancer paired‐related homeobox 1b epithelial– mesenchymal transition proliferation invasion |
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