An in vivo model of melanoma: treatment with ATP |
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Authors: | Nicholas White Gillian E Knight Peter E M Butler Geoffrey Burnstock |
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Institution: | (1) Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK;(2) Department of Plastic and Reconstructive Surgery, Royal Free Hospital, Pond Street, London, NW3 2QG, UK |
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Abstract: | Athymic mice, injected with A375 human melanoma cells, were treated daily with intraperitoneal injections of adenosine 5′-triphosphate
(ATP). The tumour volume and animal weight were measured over the course of the experiment and the final tumour nodule weight
was measured at the end of the experiment. Tumour volume decreased by nearly 50% by 7 weeks in treated mice. Weight loss in
untreated animals was prevented by ATP. Histological examination of the excised tumour nodules showed necrosis in the ATP-treated
tumours only. The presence of P2Y1 and P2X7 receptors, previously proposed as extracellular targets for melanoma treatment with ATP, were demonstrated in the excised
specimens by immunohistochemistry. This paper provides further support for the use of ATP as a treatment for melanoma. |
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Keywords: | Melanoma Cancer Purinergic signalling ATP |
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