Serotype- and strain- dependent contribution of the sensor kinase CovS of the CovRS two-component system to <Emphasis Type="Italic">Streptococcus pyogenes</Emphasis> pathogenesis |
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| Authors: | Venelina Sugareva Regina Arlt Tomas Fiedler Catur Riani Andreas Podbielski Bernd Kreikemeyer |
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| Institution: | (1) Medical Faculty, Inst. of Med. Microbiology, Virology and Hygiene, Dept. of Med. Microbiology and Hospital Hygiene, University of Rostock, Schillingallee 70, 18055 Rostock, Germany |
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| Abstract: | Background The Streptococcus pyogenes (group A streptococci, GAS) two-component signal transduction system CovRS has been described to be important for pathogenesis
of this exclusively human bacterial species. If this system acts uniquely in all serotypes is currently unclear. Presence
of serotype- or strain-dependent regulatory circuits and polarity is an emerging scheme in Streptococcus pyogenes pathogenesis. Thus, the contribution of the sensor kinase (CovS) of the global regulatory two-component signal transduction
system CovRS on pathogenesis of several M serotypes was investigated. |
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