犬腹部爆炸伤后海水浸泡的实验模型建立及早期死亡原因探讨

目的　建立犬腹部爆炸伤后海水浸泡的实验模型 ,探讨犬早期死亡原因。方法　 30只成年健康杂种犬随机分为 2组 :对照组 (n =10 )及实验组 (n =2 0 )。对照组为单纯腹部爆炸伤 ,伤后直接观察。实验组 (海水浸泡组 )为单纯腹部爆炸伤后立即置入海水中 ,在伤前及入水后 1、2、3、4h监测肛温并取血测定血浆渗透压、血钠、血钾、血氯。结果　实验组出现严重的电解质紊乱和血液高渗状态 ,表现为高渗性脱水、高钠血症、高氯血症。平均生存时间仅为 2 0 9min。对照组上述指标无明显变化 ,8h内无死亡。结论　海水浸泡后高渗性脱水、电解质紊乱和低温是实验犬致死的重要原因

Establishment of a Model of Explosive Open Abdominal Injury and Study of Risky Factors of Early Death

Objective To establish a model of explosive abdominal injury and seawater immersion and to study the risky factors of early death. Methods Thirty healthy dogs were divided into two groups: experimental group(explosive abdominal injury and seawater immersion)and control group(explosive open abdominal injury only). Blood samples were taken at eight different time intervals for assessing blood gas, plasma osmotic pressure and serum electrolytes. The hemodynamic and respiratory changes were recorded. At the end of study lung was harvested for pathologic examination. Results Post_trauma condition in experimental group was more serious than that in control group. Progressive dysfunction of respiratory and circulatory system, acute lung injury, severe hypernatremia and higher osmotic pressure were found only in experimental group. The mean survival time in experimental group was 209 minutes. Conclusion The results of this study indicates that the explosive model of abdominal injury is practicable and can be repeated well. Seawater immersion after open pneumothorax could result in severe physiopathologic changes. These risky factors appear to be associated with early death in experimental models.