| 大鼠局灶性脑缺血后扩布性阻抑的发作及电针对其影响 |
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| 作者姓名： | Luo Y Dong WW |
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| 作者单位： | 重庆医科大学附属第一医院神经内科, |
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| 基金项目： | 国家自然科学基金重点项目(39730170)及重庆市中医管理局资助课题 |
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| 摘 要： | 目的：观察Wistar大鼠局灶性脑缺血后扩布性阻抑（SD）的发作情况及缺血后电针的影响。方法：线检法闭塞大鼠大脑中动脉,制备局灶性脑缺血模型。用神经电生理、神经病理等方法检测局灶性脑缺血后3h内SD发作情况及电针“合谷”穴（LI4）对SD的影响。结果：电针可减少局灶性脑缺血时SD的发作。结论：电针减少局灶性脑缺血时SD的发作,可能与电针缩小局灶性脑梗塞体积有关。
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| 关 键 词： | 局灶性脑缺血 扩布性阻抑 电针 合谷穴 大鼠 针刺疗法 |
| 文章编号： | 1000-6834(2001)04-0320-03 |
| 修稿时间： | 2000年6月23日 |
The episodes of spreading depression during focal cerebral ischemia in rats and the effects of electroacupuncture |
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| Luo Y,Dong WW.The episodes of spreading depression during focal cerebral ischemia in rats and the effects of electroacupuncture[J].Chinese Journal of Applied Physiology,2001,17(4):320-322. |
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| Authors: | Luo Y Dong W W |
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| Institution: | Department of Neurology, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016, China. |
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| Abstract: | Aim: To investigate the effects of electroacupuncture on the episodes of spreading depression(SD) in Wistar rats during focal cerebral ischemia. Methods: A model of the middle cerebral artery occlusion(MCAo) in Wistar rats was performed with the intraluminal filament occlusion. The episodes of SD in focal cerebral ischemia within 3 hours and the effects of electroacupuncturing on "He gu" point(LI 4) were detected using neuroelectrophysiological method and neuropathological method. Results: Electroacupuncture can reduce the episodes of SD during focal cerebral ischemia.Conclusions: Electroacupuncture can reduce the infarct volume of the focal cerebral ischemia,its mechanism may relate to reducing the episodes of SD during focal cerebral ischemia. |
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| Keywords: | focal cerebral ischemia spreading depression electroacupuncture "He gu" point rat |
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