Plasma prostaglandin F metabolite concentrations following cervical encerclage |
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Authors: | PS Cocks IS Fraser R Markham M Robinson RP Shearman |
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Institution: | 1. Department of Obstetrics and Gynaecology, University of Sydney, New South Wales, 2006, Australia;2. King George V Memorial Hospital, Missenden Road, Camperdown, New South Wales, 2050, Australia |
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Abstract: | Peripheral plasma concentrations of 13, 14-dihydro-15-keto prostaglandin F2α (PGFM) were measured in seven women having elective cervical encerclage in an otherwise normal pregnancy. Three of seven patients had a statistically significant elevation of PGFM levels at 60 minutes after commencement of surgery. On the basis that the majority of patients had no significant rise and that there was no objective evidence of uterine contractions post-operatively, the routine administration of prostaglandin inhibitory agents to patients having cervical encerclage cannot be recommended. |
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