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Schistosoma mansoni: Permanence of modulation of the granulomatous inflammatory response in mice cured in the chronic phase |
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| Authors: | PMZ Coelho NH Toppa JS Feldmann R Gonçalves RT Mello |
| Institution: | * Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Caixa Postal 486, 30161-970, Belo Horizonte MG, Brazil ‡ Departmento de Anatomia Patológica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte MG, Brazil § Departmento de Análises Clinicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte MG, Brazil |
| Abstract: | Persistence of down regulation of granoloma size was studied in mice chronically infected with Schistosoma mansoni and cured by chemotherapy. The animals were reinfected at 20-, 50-, 110- and 140-day intervals after treatment, and sacrificed 60 days post-reinfection. Reinfected animals were able to modulate the granulomatous inflammatory response, thus preventing a new acute phase. These findings may contribute to the explanation for the decrease of morbidity from human schistosomiasis seen in endemic areas following mass treatment. |
| Keywords: | Author Keywords: Schistosoma mansoni granuloma immunomodulation immunoregulation chemotherapy immunopathology reinfection experimental schistosomiasis |
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