14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr |
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| Authors: | Diane L Bolton Robert A Barnitz Keiko Sakai Michael J Lenardo |
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| Affiliation: | (1) Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;(2) ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;(3) Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan |
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| Abstract: | Background Despite continuing advances in our understanding of AIDS pathogenesis, the mechanism of CD4+ T cell depletion in HIV-1-infected individuals remains unclear. The HIV-1 Vpr accessory protein causes cell death, likely through a mechanism related to its ability to arrest cells in the G2,M phase. Recent evidence implicated the scaffold protein, 14-3-3, in Vpr cell cycle blockade. |
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