Balance between matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in the cervical mucus plug estimated by determination of free non-complexed TIMP |
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| Authors: | Naja Becher Merete Hein Niels Uldbjerg Carl Christian Danielsen |
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| Affiliation: | 1.Department of Obstetrics and Gynecology,?rhus University Hospital, Skejby,Aarhus N,Denmark;2.Department of Connective Tissue Biology,Institute of Anatomy, University of Aarhus,Aarhus C,Denmark |
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| Abstract: | Background The cervical mucus plug (CMP) is a semi-solid structure with antibacterial properties positioned in the cervical canal during pregnancy. The CMP contains high concentrations of matrix metalloproteinase 8 and 9 (MMP-8, MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1). This indicates a potential to degrade extracellular matrix components depending on the balance between free non-complexed inhibitors and active enzymes. |
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