LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar typhimurium |
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| Authors: | Karavolos M H Bulmer D M Winzer K Wilson M Mastroeni P Williams P Khan C M A |
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| Affiliation: | Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom. |
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| Abstract: | LuxS catalyzes the synthesis of the quorum-sensing signaling molecule autoinducer 2. We show that in Salmonella enterica serovar Typhimurium, deletion of the luxS gene polarizes flagellar phase variation toward the more immunogenic phase 1 flagellin. This phenotype is complementable by luxS in trans but is independent of quorum-sensing signals. |
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