Platelets: Pleiotropic roles in atherogenesis and atherothrombosis |
| |
| Authors: | Matthew D Linden Denise E Jackson |
| |
| Institution: | 1. School of Medical Sciences, RMIT University, Plenty Road Bundoora, VIC, Australia;2. Health Innovations Research Institute, RMIT University, VIC, Australia;1. Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL;2. Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL;;3. Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom;;4. Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL;1. Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, USA;2. Division of Biostatistics, Department of Population Health, New York University School of Medicine, New York, NY, USA;3. Division of Vascular Surgery, Department of Surgery, New York University School of Medicine, New York, NY, USA;4. Division of Hematology, Department of Medicine, New York University School of Medicine, New York, NY, USA;1. Department of Biochemistry, University of Pavia, Pavia, Italy;;2. Molecular Biotechnology Center, University of Turin, Turin, Italy;;3. Queen Mary University of London, London, United Kingdom; and;4. Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan;1. Department of Cardiology, The 1st Hospital of Qiqihar, Qiqihar, China;2. Department of Cardiology, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China;3. Department of Cardiology, The 1st Affiliated Hospital of Harbin Medical University, Harbin, China;4. Department of Cardiology, Yiwu Central Hospital, Yiwu, China;1. Université de Strasbourg, INSERM, Etablissement Français du Sang-Alsace, Biologie et Pharmacologie des Plaquettes Sanguines Unité Mixte de Recherche–S 949, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France;;2. Center for Stem Cell Research, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX;;3. Center for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan; and;4. Mesoblast Ltd., Melbourne, VIC, Australia |
| |
| Abstract: | Platelets are small, anucleate blood elements of critical importance in cardiovascular disease. The ability of platelets to activate and aggregate to form blood clots in response to endothelial injury, such as plaque rupture, is well established. These cells are therefore important contributors to ischaemia in atherothrombosis, and antiplatelet therapy is effective for this reason. However, growing evidence suggests that platelets are also important mediators of inflammation and play a central role in atherogenesis itself. Interactions between activated platelets, leukocytes and endothelial cells trigger autocrine and paracrine activation signals, resulting in leukocyte recruitment at and into the vascular wall. Direct physical interaction may contribute also, through platelet adhesion molecules assisting localization of monocytes to the site of atherogenesis and platelet granule release contributing to the chronic inflammatory milieu which leads to foam cell development and accelerated atherogenesis. Recent studies have shown that antiplatelet therapy in animal models of accelerated atherogenesis can lead to decreased plaque size and improve plaque stability. This review examines the complexity of platelet function and the nature of interactions between activated platelets, leukocytes and endothelial cells. We focus on the growing body of evidence that platelets play a critical role in atherogenesis and contribute to progression of atherosclerosis. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
