Tenascin-W: An extracellular matrix protein associated with osteogenesis and cancer |
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| Authors: | Enrico Martina Ruth Chiquet-Ehrismann Florence Brellier |
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| Affiliation: | 1. Laboratoire des Venins et Molécules Thérapeutiques, Institut Pasteur Tunis, 13 Place Pasteur, BP74, 1002, Tunis- Université Tunis El Manar Tunisia, Tunisia;2. INSERM U1109, Tumor Microenvironment Group, 1 Place de L’Hôpital, 67091, Strasbourg, France;3. Service de Radiologie, Hôpital Mongi Slim-La Marsa-Tunisia, Tunisia;4. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland;5. Service Anatomopathologie, Institut Pasteur Tunis, 13 Place Pasteur, BP74, 1002, Tunis- Université Tunis El Manar Tunisia, Tunisia;6. Faculté de Médecine de Tunis, 15 Rue Djebel Lakhdhar, La Rabta, 1007, Tunis-Université Tunis el Manar, Tunisia;1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;2. Laboratory of Neuro-oncology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China;1. Department of Bioengineering, Rice University, Houston, TX, USA;2. Department of Biomedical Engineering, Duke University, Durham, USA;1. The Microenvironmental Niche in Tumorigenesis and Targeted Therapy, INSERM U1109 - MN3T, 3 Avenue Molière, 67200 Strasbourg, France;2. Université de Strasbourg, 67000 Strasbourg, France;3. LabEx Medalis, Université de Strasbourg, 67000 Strasbourg, France;4. Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67000 Strasbourg, France;5. Institute of Molecular Medicine and Cell Research, University of Freiburg, 79104 Freiburg, Germany;6. BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany;7. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;8. iBV, INSERM, CNRS, Université Côte d’Azur, 06108 Nice, France |
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| Abstract: | Tenascin-W was the last member of a family of four large extracellular matrix glycoproteins to be discovered. The original member of the tenascin family, tenascin-C, has been widely studied due to its association with asthma, fibrosis, infection, inflammation and cancer. Recent studies report multiple common features between tenascin-W and tenascin-C in terms of structure, expression and function, especially in the context of tumorigenesis. Furthermore, specific functions for tenascin-W in osteogenesis have been revealed. This review presents an update on our current knowledge concerning tenascin-W and discusses potential medical applications of this cancer-enriched extracellular matrix protein. |
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