The Yin and Yang of bone morphogenetic proteins in cancer |
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| Authors: | Ashok Singh Rebecca J. Morris |
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| Affiliation: | 1. Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States;2. Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, United States;3. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States;4. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, United States;5. Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan;6. Department of Biologic and Materials Sciences, the University of Michigan School of Dentistry, Ann Arbor, MI 48109, United States;7. Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, United States;1. Department of Gastroenterology and Hepatology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands;4. Department of Radiology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands;7. Department of Pathology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands;12. Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands;2. Department of Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands;3. Center for Inflammatory Bowel Diseases, University of California Los Angeles Medical Center, Santa Monica, California;5. Percuros B.V., Leiden, The Netherlands;6. Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands;9. Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands;10. Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands;8. Department of Pathology, University Medical Center, Utrecht, The Netherlands;11. Department of Gastroenterology and Hepatology, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands;1. Gastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;2. Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;3. Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Ehime, Japan;4. Ludwig Institute for Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, 75124 Uppsala, Sweden;5. Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, 75123 Uppsala, Sweden;1. College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Republic of Korea |
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| Abstract: | Bone morphogenetic proteins (BMPs) were first studied as growth factors or morphogens of the transforming growth factor-beta superfamily. These growth molecules, originally associated with bone and cartilage development, are now known to play an important role in morphogenesis and homeostasis in many other tissues. More recently, significant contributions from BMPs, their receptors, and interacting molecules have been linked to carcinogenesis and tumor progression. On the other hand, BMPs can sometimes function as a tumor suppressor. Our report highlights these new roles in the pathogenesis of cancer that may suggest novel targets for therapeutic intervention. |
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