The cell biology of hepatitis C virus (HCV) lipid addiction: Molecular mechanisms and its potential importance in the clinic |
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| Authors: | Eric Piver Philippe Roingeard Jean-Christophe Pagès |
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| Institution: | 1. INSERM U966, Université François Rabelais de Tours, Faculté de Médecine, 10 Bd Tonnellé, 37000 Tours, France;2. Service de Biochimie et Biologie Moléculaire, CHRU de Tours, France;3. Service de Biologie Cellulaire, CHRU de Tours, France;1. Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA;2. The State University of New York at Buffalo, Buffalo, NY, USA;3. Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, USA;4. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA;5. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA;1. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;2. Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom;3. Institute of Translational & Stratified Medicine, Plymouth University Peninsula School of Medicine & Dentistry, United Kingdom;4. Inserm U1110, University of Strasbourg and Center for Liver and Digestive Diseases, Strasbourg University Hospitals, 3 Rue Koeberlé, F-67000 Strasbourg, France;5. Liver Unit, Department of Medicine, Imperial College London, St Mary’s Hospital Campus, Praed Street, London, United Kingdom;6. Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montréal (IRCM), Montréal, Canada;7. Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montréal, Montréal, Canada;8. Department of Clinical Biochemistry, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, United Kingdom;9. University of Montréal, Montréal, Canada;1. Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, United States;2. Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States;3. University of Geneva, Geneva, Switzerland;4. University of Queensland, Brisbane, Australia;5. Gilead Sciences, Foster City, CA, United States;6. Division of Gastroenterology, Duke University Medical Center, Durham, NC, United States |
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| Abstract: | Hepatitis C virus (HCV) is a major cause of chronic hepatitis associated with liver steatosis, commonly evolving to cirrhosis or hepatocellular carcinoma. The World Health Organisation (WHO) estimates that there are around 170 million chronic HCV carriers worldwide. The virus has a highly variable sequence, allowing definition of seven genotypes with different geographical distributions. Both clinical outcome and response to antiviral therapy are strongly influenced by HCV genotype. Importantly, several recent papers have suggested that the lipid profile of infected patients is strongly indicative of the various clinical outcomes of HCV infection. Furthermore, viral molecular and cellular studies have shown a tight link between cellular lipid metabolism and almost every step of the HCV infectious cycle. In the present review we summarise the current knowledge establishing the interplay between the molecular features of HCV replication, the cellular lipid biology and the lipid profiles observed in the serum of infected patients. |
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