An outbreak of the desert sub-type of zoonotic visceral leishmaniasis in Jiashi,Xinjiang Uygur Autonomous Region,People's Republic of China |
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| Authors: | Jun-Yun Wang Chun-Hua Gao Yue-Tao Yang Hai-Tang Chen Xue-Hua Zhu Shan Lv Sheng-Bang Chen Su-Xiang Tong Peter Steinmann Kathrin Ziegelbauer Xiao-Nong Zhou |
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| Institution: | 1. Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, 046000, PR China;2. Department of Hematology, Peace Hospital of Changzhi Medical College, Changzhi, 046000, PR China;3. Department of Ear, Nose, and Throat, Peace Hospital of Changzhi Medical College, Changzhi, 046000, PR China;4. Department of Ultrasound Diagnosis, Peace Hospital of Changzhi Medical College, Changzhi, 046000, PR China;5. Department of Radiology, Putuo District Central Hospital, Shanghai, 200062, PR China;6. Institute of Genetic Engineering, Southern Medical University, Guangzhou, 510515, PR China;7. Center for Post-doctoral Studies in Southern Medical University, Guangzhou, 510515, PR China;8. Guangdong Provincial Key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China;1. Department of Marine Biology, Texas A&M University at Galveston, Galveston, TX 77553, USA;2. Institute of Marine Science, The University of Alaska Fairbanks, Fairbanks, AK 99775, USA;3. Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomon, MD 20688, USA |
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| Abstract: | Few outbreaks of the desert sub-type of zoonotic visceral leishmaniasis (VL) have been described worldwide. In 2008, the incidence rate of VL in Jiashi County, Xinjiang Uygur Autonomous Region in the western part of the People's Republic of China, increased more than twenty-folds compared to the average annual incidence rate. The majority of the cases (96.6%) occurred among < 2 year-old infants. For the first time in the desert area of Xinjiang, the parasites were isolated from bone marrow aspirates, using the NNN medium culture approach. The genetic analysis of the ITS-1 nucleotide sequence indicated that three isolates from eastern Jiashi County were genetically closely related and belonged to the Leishmania infantum group. However, they differed from an isolate from Kashi city which was classified as a member of the Leishmania donovani group. |
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