Artesunate,a potential drug for treatment of Babesia infection |
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| Authors: | Youn-Kyoung Goo M Alaa Terkawi Honglin Jia G Oluga Aboge Hideo Ooka Bryce Nelson Suk Kim Fujiko Sunaga Kazuhiko Namikawa Ikuo Igarashi Yoshifumi Nishikawa Xuenan Xuan |
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| Institution: | 1. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan;2. College of Veterinary Medicine & Research Institute of Life Science, Gyeongsang National University, Jinju, Gyeongnam 660-701, Republic of Korea;3. School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 229-8501, Japan;1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, PR China;2. Department of Pain Management, The First Affiliated Hospital of Jinan University, Guangzhou 510630, PR China;1. Hammersmith Hospital, Imperial College London, UK;2. Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, UK;3. Breakspear Medical Group, Hemel Hempstead, Hertfordshire, UK;1. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan;2. Laboratory of Molecular Genetic, Institute of Veterinary Medicine, Zaisan 210153, Ulaanbaatar, Mongolia;3. Department of Parasitology, Faculty of Veterinary Medicine, Minoufiya University, Sadat City, Minoufiya, Egypt;1. Department of Zoology, Faculty of Science, Minufiya University, Shebin El-Kom, Egypt;2. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan;3. Veterinary Services Department, Cairo, Egypt;1. Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, CZ-370 05 Ceske Budejovice, Czech Republic;2. Faculty of Science, University of South Bohemia, CZ-370 05 Ceske Budejovice, Czech Republic;3. Instituto de Patobiología Veterinaria, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas (CICVyA), INTA-Castelar, Los Reseros y Nicolas Repetto s/n, Hurlingham 1686, Argentina;4. National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires C1033AAJ, Argentina;1. Division of Parasitology, Kimron Veterinary Institute, 50250 Bet Dagan, Israel;2. Department of Microbiology and Molecular Genetics, The Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University of Jerusalem, Jerusalem, Israel;3. Department of Pathology and Bosch Institute, The University of Sydney, Sydney, Australia;4. Centre of Excellence for Pharmaceutical Sciences, North West University, Potchefstroom, South Africa |
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| Abstract: | The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260 μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6 μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10 mg/kg of body weight on days 8–10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection. |
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